Affiliation:
Department of Microbiology
National Taiwan University
E-mail address: tsaikunli@ntu.edu.tw
Detail PDF
URL：https://scholars.lib.ntu.edu.tw/cris/rp/rp06152
Academic History:
-(1991)Department of Microbiology
BD in Microbiology
Soochow University, Taiwan, ROC
-(1999)Department of Pharmacology,
PhD in Pharmacology
Rutgers University & University of Medicine and Dentistry of New Jersey, USA
Professional/Scientific Career:
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1987- 1990
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Voluntary Research Assistant
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Soochow University, Taiwan, ROC
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1993- 1994
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Research Assistant
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Institute of Molecular Biology
Academia Sinica, Taiwan, ROC
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1999- 2003
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Postdoctoral Fellow
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Rutgers University & University of Medicine and Dentistry of New Jersey, USA
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2000- 2003
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Research Teaching Specialist
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Rutgers University & University of Medicine and Dentistry of New Jersey, USA
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2001- 2001
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Visiting Scientist
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Institute of Molecular Biology
Academia Sinica, Taiwan, ROC
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2003- 2007
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Assistant Professor
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Dept. & Graduate Institute of Microbiology, National Taiwan University, Taiwan, ROC
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2007- 2011
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Associate Professor
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Dept. & Graduate Institute of Microbiology,
National Taiwan University, Taiwan, ROC
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2008- Now
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Principal Investigator
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Center for Biotechnology
National Taiwan University, Taiwan, ROC
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2008- Now
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Chief
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Division of Research and Development,
Center for Biotechnology,
National Taiwan University, Taiwan, ROC
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2011- Now
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Professor
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School of Integrative and Global Majors,
University of Tsukuba, Tsukuba, Japan
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2011- Now
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Professor
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Dept. & Graduate Institute of Microbiology,
National Taiwan University, Taiwan, ROC
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2012- Now
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Director
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Office for International Affairs, NTUCM,
National Taiwan University, Taiwan, ROC
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2012- Now
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Associate Dean
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College of Medicine,
National Taiwan University, Taiwan, ROC
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2015- Now
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Associate Editor
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Journal "Genes to Cell", Japan
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2015- Now
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PI
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NTU SPARK Program,
Taiwan Supra Integration and Incubation Center
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2015- Now
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CEO
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NTU Center for Genome Medicine,
National Taiwan University, Taiwan, ROC
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Awards/Professional Societies:
Topoisomerases, Topoisomerase-targeting drugs, DNA damage and repair.
• DNA topology and its biological implications
• Topoisomerases and their targeting drugs
• Repair and signaling pathways for DNA damage
Research Area/ Interests:
The research conducted in my laboratory combines both molecular and biochemical approaches toward investigating the following interrelated programs of research:
Roles of DNA topoisomerases in DNA organization: Topoisomerases are ubiquitous, essential nuclear enzymes that participate in the regulation of DNA different topological states by transient breakage and rejoining of DNA. Cellular functions of different topoisomerases are currently under investigation.
Studies on topoisomerase-mediated DNA damage: Due to its delicate act of breaking/rejoining DNA, topoisomerase is highly vulnerable while performing its enzymatic reaction on DNA. In agreement with this notion, DNA topoisomerases have been firmly established as highly effective molecular targets for antibiotics (e.g. quinolones) and anti-tumor drugs (e.g. camptothecins). Our lab also interested in understanding the molecular determinants for topoisomerase-targeting conditions.
Post-translational modification of DNA topoisomerases: Modification and proteolytic pathways have been suggested to participate in regulating functions and activities of DNA topoisomerases. For example, ubiqutin/26S proteasome pathway has been implicated to degrade topoisomerases from cleavable complexes.
Publications * corresponding author
Selected publications (Original article, ; Review, )
1. Yeh Y-H, Wang S-W, Yeh Y-C, Hsiao H-F, Li T-K* (2016) Rhapontigenin inhibits TGF--mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1 degradation Oncol Rep. May, 35(5): 2887-95.
2. Chou S-M, Lai W-J, Hong T, Tsai S-H, Chen Y-H, Kao C-H, Chu R, Shen T-L*, Li T-K* (2015) Involvement of p38 MAPK in the Anticancer Activity of Cultivated Cordyceps militaris. Am. J. Chin. Med. 43(5): 1043-57.
3. Hsieh M-Y, Fan J.R., Chang H-W, Chen H-C, Shen T.-L., Teng SC, Yeh Y-H, Li T-K*. (2014) DNA topoisomerase IIIalpha cooperates with p53 in senescence and tumor-suppression. Clinical Cancer Research. 20(6): 1489-501.
4. Yeh Y-H, Yang Y-C, Hsieh M-Y, Yeh Y-C, Li T-K*. (2013) A negative feedback of the HIF-1 pathway via interferon-stimulated gene 15 and ISGylation. Clinical Cancer Research, 19(21): 5927-39.
5. Wu, C-C, Li, T-K*, Farh L, Lin LY, Lin TS, Yu YJ, Yen TJ, Chiang CW and Chan NL. (2011) Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide. Science. 333:459-62.
