Shu-Chun Teng, Ph.D.                                           

Affiliation: 

Department of Microbiology

College of Medicine

National Taiwan University 

E-mail address: shuchunteng@ntu.edu.tw

Detail (PDF)

URL:  https://scholars.lib.ntu.edu.tw/cris/rp/rp06150

Academic History:

- (1989)Chemistry,B.S. in Chemistry,

  National Taiwan University, Taiwan, ROC

- (1996)Biochemistry and Molecular Biology, PhD in Biochemistry and Molecular Biology, 

  Rutgers University, USA

Professional/Scientific Career:

Awards/Professional Societies:

1.Blue Apricot Medical Award, Taiwan, 2011

2.NSC Excellent Scholar Award, Taiwan, 2009

3.NTU Excellent Research Award, Taiwan, 2009

4.Young Investigator Award, Yung Shin Tian-De Lee Medical and Pharmaceutical Science and

    Technology, Taiwan, 2008

5.Academia Sinica Research Award for Junior Research Investigators, Taiwan, 2004

6.Da-You Wu Memorial Award, National Science Council, Taiwan, 2003

7.Fellow, Department of Defense, U.S. Army Breast Cancer Research, 1997~2000

8.Rutgers Predoctoral Fellowship, 1991

Research Area/ Interests:

Stress Response and Aging

Research in our lab is centered around the molecular basis of genome dynamics and stress response in cancer and aging by systematically identifying both enzymatic and structural components involved in the chromosome dynamics, stress response and aging pathways, and characterizing how these proteins work. Genomic instability is the leading cause for disease and telomere maintenance is a required step for cancer and aging. We take advantage of the genetically tractable model organisms yeast Saccharomyces cerevisiae and Schizosaccharomyces pombe to approach these questions and use our findings in yeast to extend our studies in mammalian cells, since the fundamental mechanisms of these pathways are preserved from yeast to human.

Publications  * corresponding author

Selected publications (Original article, ; Review,  )　

1.Shen, Z.-J. and Hsu, P.-H. and Su, Y.-T. and Yang, C.-W. and Kao, L. and Tseng, S.-F. and Tsai, M.-D. and Teng, S.-C., NTU: SHU-CHUN TENG, Corrigendum: PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phaseNature Communications2015, journal-articlevol.6 

2.Chang, Y.-L. and Hsieh, M.-H. and Chang, W.-W. and Wang, H.-Y. and Lin, M.-C. and Wang, C.-P. and Lou, P.-J. and Teng, S.-C., NTU: SHU-CHUN TENG, Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeastAntioxidants and Redox Signaling2015, journal-articlevol.22,no.7,page.587-602 

3.Kuo, Y.-C. and Wu, H.-T. and Hung, J.-J. and Chou, T.-Y. and Teng, S.-C. and Wu, K.-J., NTU: SHU-CHUN TENG, Nijmegen breakage syndrome protein 1 (NBS1) modulates hypoxia inducible factor-1α (HIF-1α) stability and promotes in vitro migration and invasion under ionizing radiationInternational Journal of Biochemistry and Cell Biology2015, journal-articlevol.64,page.229-238 

4.Hsieh, M.-H. and Tsai, C.-H. and Lin, C.-C. and Li, T.-K. and Hung, T.-W. and Chang, L.-T. and Hsin, L.-W. and Teng, S.-C., NTU: SHU-CHUN TENG, Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancersCellular and molecular life sciences : CMLS2015, journal-articlevol.72,no.9,page.1825-1837 

5.Hsieh, M.-Y. and Fan, J.-R. and Chang, H.-W. and Chen, H.-C. and Shen, T.-L. and Teng, S.-C. and Yeh, Y.-H. and Li, T.-K., NTU: SHU-CHUN TENG,  TSAI-KUN LI, DNA topoisomerase III alpha regulates P53-mediated tumor suppressionClinical Cancer Research2014 , journal-articlevol.20,no.6,page.1489-1501